Doctor B.J. Casey
Lecture Abstract
Windows into the Developing Human Brain
Attention Deficit Hyperactivity Disorder (ADHD) is a common and impairing developmental disorder with onset at preschool age. Although a significant amount of progress has been made investigating the neurobiology of this disorder, its precise etiology still remains unclear, presumably because there are multiple paths to the development of the disorder. Converging evidence from studies from neuropsychology, neuroimaging, neuropharmacology, and genetics of ADHD suggest delayed or disrupted development of fronto-striatal-cerebellar circuitry and related neurochemistry resulting in immature or disrupted regulation of behavior. This presentation will provide a working model of cognitive control and evidence for its development, neurobiological basis and disruption in ADHD from imaging, lesion, environmental and genetic studies.
Casey, B.J. (2002) Windows into the Human Brain. Science, 296: 1409-1410.
Casey, BJ, Thomas, K.M., Davidson, M.C., Kunz, K. & Franzen, P.L. (2002). Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus-Response Compatibility Task. J. Neuroscience, 22: 8647-8652.
Casey, BJ, Tottenham, N. & Fossella, J. (2002). Clinical, lesion, imaging and genetic approaches to the study of inhibitory mechanisms of attention. Developmental Psychobiology. 40:237-254.
